abstract：:We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted a literature review and a microbiological investigation, including that of clinical and environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-y...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Almeida JN Jr,Francisco EC,Barberino MGMA,Silva LVRFD Filho,Brandão OM,Colombo AL,Padovan ACB

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE:This study verified the influence of non-parasitic wound infe...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Antonio LF,Lyra MR,Saheki MN,Schubach AO,Miranda LFC,Madeira MF,Lourenço MCDS,Fagundes A,Ribeiro ÉADS,Barreto L,Pimentel MIF

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects i...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Irion CI,Paredes BD,Brasil GV,Cunha STD,Paula LF,Carvalho AR,Carvalho ACC,Carvalho AB,Goldenberg RCDS

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that human papillomavirus (HPV) intratype variants (specific lineages and sublineages) are associated with pathogenesis and progression from HPV infection to persistence and the development of cervical cancer. OBJECTIVES:This study aimed to verify the prevalence of HPV infection...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Oliveira GR,Vieira VC,Ávila EC,Finger-Jardim F,Caldeira TD,Gatti FA,Gonçalves CV,Oliveira SG,da Hora VP,Soares MA,de Martinez AM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Enterocytozoon bieneusi are the most common microsporidia associated with different clinical manifestations such as diarrhoea, respiratory tract inflammation and acalculous cholecystitis, especially in immunocompromised patients. Infection usually occurs by ingestion of food and water contaminated with spore...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Yamashiro S,Fiuza VRDS,Teixeira ÂTLS,Branco N,Levy CE,Castro ICVS,Franco RMB

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector contr...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Russomando G,Cousiño B,Sanchez Z,Franco LX,Nara EM,Chena L,Martínez M,Galeano ME,Benitez L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The time of progression towards AIDS can vary greatly among seropositive patients, and may be associated with host genetic variation. The NR1I2 (PXR) gene, a ligand-activated transcription factor, regulates the transcription immune pathway genes and can therefore be targets of viral replication mechanisms in...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Medeiros RM,Menti CF,Benelli JL,Matte MC,Melo MG,Almeida SE,Fiegenbaum M

更新日期：2017-04-01 00:00:00

abstract：:Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America. Although the pathogenesis of Chagas cardiomyopathy is incompletely understood, it may involve several mechanisms, including parasite-dependent my...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Rassi A Jr,Marin JA Neto,Rassi A

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Gene reporter-fluorescent cells have emerged as alternative method for drug screening. OBJECTIVE:Achievement of constitutive expression of fluorescent protein GFP by Leishmania braziliensis as alternative method for drug screening. METHODS:L. braziliensis-GFP was generated using Leishmania tarentolae pLEXS...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bastos MS,Souza LÂ,Onofre TS,Silva A Júnior,Almeida MR,Bressan GC,Fietto JL

更新日期：2017-02-01 00:00:00

abstract：:A pleiotropic response to the calpain inhibitor MDL28170 was detected in the tomato parasite Phytomonas serpens. Ultrastructural studies revealed that MDL28170 caused mitochondrial swelling, shortening of flagellum and disruption of trans Golgi network. This effect was correlated to the inhibition in processing of cru...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira SS,Gonçalves DS,Garcia-Gomes AD,Gonçalves IC,Seabra SH,Menna-Barreto RF,Lopes AH,D'Avila-Levy CM,Santos AL,Branquinha MH

更新日期：2017-01-01 00:00:00

abstract：:Studies on the sandfly fauna to evaluate natural infection indexes are still limited in the Brazilian Amazon, a region with an increasing incidence of cutaneous leishmaniasis. Here, by using a multiplex polymerase chain reaction directed to Leishmania kDNA and hybridisation, we were able to identify L. (Viannia) subge...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Araujo-Pereira T,Pita-Pereira D,Boité MC,Melo M,Costa-Rego TA,Fuzari AA,Brazil RP,Britto C

更新日期：2017-01-01 00:00:00

abstract：:Integration of human papillomavirus (HPV) DNA into human cells accompanied by the disruption of the viral genome has been described as a prerequisite for cancer development. This study aimed to investigate E2 gene integrity of HPV16 and HPV58 viruses isolated from infected women with cervical lesions. Forty-two HPV16-...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： González-Losa MD,Puerto-Solis M,Tenorio Ruiz J,Rosado-López AI,Hau-Aviles O,Ayora-Talavera G,Cisneros-Cutz I,Conde-Ferráez L

更新日期：2016-12-01 00:00:00

abstract：:Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir a...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pontoriero A,Avaro M,Benedetti E,Russo M,Czech A,Periolo N,Campos A,Zamora A,Baumeister E

更新日期：2016-12-01 00:00:00

abstract：:Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosynthesis. Angomonas deanei is an example of a symbiont-containing trypa...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Penha LL,Hoffmann L,Souza SS,Martins AC,Bottaro T,Prosdocimi F,Faffe DS,Motta MC,Ürményi TP,Silva R

更新日期：2016-11-01 00:00:00

abstract：:Given their medical and veterinary relevance, the members of the Pipiens Assemblage are a worldwide target of ecological research. The distribution of Culex pipiens s.s. and Cx. quinquefasciatus converge in Buenos Aires, Argentina, where hybrids have been detected. Each member of the assemblage exhibits a distinct eco...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cardo MV,Rubio A,Junges M,Vezzani D,Carbajo AE

更新日期：2016-11-01 00:00:00

abstract：:Major emergency efforts are being mounted for each vector-borne disease epidemiological crisis anew, while knowledge about the biology of arthropods vectors is dwindling slowly but continuously, as is the number of field entomologists. The discrepancy between the rates of production of knowledge and its use and need f...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Casas J,Lazzari C,Insausti T,Launois P,Fouque F

更新日期：2016-11-01 00:00:00

abstract：:The Americas are presently experiencing the most serious known outbreak of Zika virus (ZIKV). Here, we present a novel set of analyses using environmental characteristics, vector mosquito distributions, and socioeconomic risk factors to develop the first map to detail global ZIKV transmission risk in multiple dimensio...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Samy AM,Thomas SM,Wahed AA,Cohoon KP,Peterson AT

更新日期：2016-09-01 00:00:00

abstract：:This study aimed to analyse the spatial distribution of human (2007-2013) and canine (2013) visceral leishmaniasis (VL) in the city of Araçuaí, Minas Gerais, Brazil, and identify the socio-environmental factors related to their occurrence. The spatial distribution of human and canine cases was analysed by kernel densi...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ursine RL,Dias JV,Morais HA,Pires HH

更新日期：2016-07-04 00:00:00

abstract：:This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Niborski LL,Grippo V,Lafón SO,Levitus G,García-Bournissen F,Ramirez JC,Burgos JM,Bisio M,Juiz NA,Ayala V,Coppede M,Herrera V,López C,Contreras A,Gómez KA,Elean JC,Mujica HD,Schijman AG,Levin MJ,Longhi SA

更新日期：2016-05-24 00:00:00

abstract：:An unusually high incidence of microcephaly in newborns has recently been observed in Brazil. There is a temporal association between the increase in cases of microcephaly and the Zika virus (ZIKV) epidemic. Viral RNA has been detected in amniotic fluid samples, placental tissues and newborn and fetal brain tissues. H...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Noronha Ld,Zanluca C,Azevedo ML,Luz KG,Santos CN

更新日期：2016-05-01 00:00:00

abstract：:In the present paper, we announce new draft genomes of four Leptospira interrogans strains named Acegua, RCA, Prea, and Capivara. These strains were isolated in the state of Rio Grande do Sul, Brazil, from cattle, dog, Brazilian guinea pig, and capybara, respectively. ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Kremer FS,Eslabão MR,Jorge S,Oliveira NR,Labonde J,Santos MN,Monte LG,Grassmann AA,Cunha CE,Forster KM,Moreno LZ,Moreno AM,Campos VF,McBride AJ,Pinto LS,Dellagostin OA

更新日期：2016-04-01 00:00:00

abstract：:This study investigated the rate of human papillomavirus (HPV) persistence, associated risk factors, and predictors of cytological alteration outcomes in a cohort of human immunodeficiency virus-infected pregnant women over an 18-month period. HPV was typed through L1 gene sequencing in cervical smears collected durin...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Meyrelles AR,Siqueira JD,Santos PP,Hofer CB,Luiz RR,Seuánez HN,Almeida G,Soares MA,Soares EA,Machado ES

更新日期：2016-02-01 00:00:00

abstract：:Chronic Chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. The aim of this research was to review commercial enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) diagnostic test performance. Performance of commercial ELISA or PCR for the diagnosis of chron...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Brasil PE,Castro R,Castro Ld

更新日期：2016-01-01 00:00:00

abstract：:Studies on natural infection by Leishmania spp of sandflies collected in endemic and nonendemic areas can provide important information on the distribution and intensity of the transmission of these parasites. This study sought to investigate the natural infection by Leishmaniain wild female sandflies. The specimens w...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira EF,Casaril AE,Mateus NL,Murat PG,Fernandes WS,Oshiro ET,Oliveira AG,Galati EA

更新日期：2015-12-01 00:00:00

abstract：:Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of the Leptospira genus. Vaccination with bacterins has severe limitations. Here, we evaluated the N-terminal region of the leptospiral immunoglobulin-like B protein (LigBrep) as a vaccine candidate against leptospirosis using immunisation strategies...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Forster KM,Hartwig DD,Oliveira TL,Bacelo KL,Schuch R,Amaral MG,Dellagostin OA

更新日期：2015-12-01 00:00:00

abstract：:A case-control study was conducted to determine the presence ofMycobacterium lepraeDNA in nasal secretions of leprosy cases and nonleprosy individuals in Fortaleza, Brazil. It included 185 cases identified by physicians at the Dona Libânia National Reference Centre for Sanitary Dermatology (CDERM). A control group (Co...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Lima LN,Frota CC,Mota RM,Almeida RL,Pontes MA,Gonçalves Hde S,Rodrigues LC,Kendall C,Kerr L

更新日期：2015-11-01 00:00:00

abstract：:In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmania species. Few reports of Leishmania (Viannia) naiffi infection suggest that its occurrence is uncommon and the reported cases...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Fagundes-Silva GA,Romero GA,Cupolillo E,Yamashita EP,Gomes-Silva A,Guerra JA,Da-Cruz AM

更新日期：2015-09-01 00:00:00

abstract：:The protective effect of infectious agents against allergic reactions has been thoroughly investigated. Current studies have demonstrated the ability of some helminths to modulate the immune response of infected hosts. The objective of the present study was to investigate the relationship between Toxocara canis infect...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Zaia MG,Oliveira SR,Castro CA,Soares EG,Afonso A,Monnazzi LG,Peitl Filho O,Faccioli LH,Anibal Fde F

更新日期：2015-09-01 00:00:00

abstract：:In the Americas, hantaviruses cause severe cardiopulmonary syndrome (HCPS) with a high fatality rate. Hantavirus infection is commonly diagnosed using serologic techniques and reverse transcription-polymerase chain reaction. This paper presents a novel plaque reduction neutralisation test (PRNT) for detecting antibodi...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pádua Md,Souza WM,Lauretti F,Figueiredo LT

更新日期：2015-08-01 00:00:00

abstract：:The primary objective of this study was to estimate the prevalence of this disease in women of childbearing age and children treated at health centres in underserviced areas of the city of Buenos Aires. Demographic and Chagas disease status data were collected. Samples for Chagas disease serology were obtained on filt...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Moscatelli G,Berenstein A,Tarlovsky A,Siniawski S,Biancardi M,Ballering G,Moroni S,Schwarcz M,Hernández S,García-Bournissen F,Cozzi AE,Freilij H,Altcheh J

更新日期：2015-08-01 00:00:00

abstract：:An increasing amount of research has been conducted on immunoglobulin Y (IgY) because the use of IgY offers several advantages with respect to diagnostic testing, including its easy accessibility, low cost and translatability to large-scale production, in addition to the fact that it can be ethically produced. In a pr...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bentes GA,Lanzarini NM,Lima LR,Manso PP,da Silva Ados S,Mouta Junior Sda S,Guimarães JR,de Moraes MT,Pelajo-Machado M,Pinto MA

更新日期：2015-06-01 00:00:00

abstract：:We describe a simple method for detection of Plasmodium vivax and Plasmodium falciparum infection in anophelines using a triplex TaqMan real-time polymerase chain reaction (PCR) assay (18S rRNA). We tested the assay on Anopheles darlingi and Anopheles stephensi colony mosquitoes fed with Plasmodium-infected blood meal...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bickersmith SA,Lainhart W,Moreno M,Chu VM,Vinetz JM,Conn JE

更新日期：2015-06-01 00:00:00

abstract：:The recommended treatment for latent tuberculosis (TB) infection in adults is a daily dose of isoniazid (INH) 300 mg for six months. In Brazil, INH was formulated as 100 mg tablets. The treatment duration and the high pill burden compromised patient adherence to the treatment. The Brazilian National Programme for Tube...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Daher A,Pitta L,Santos T,Barreira D,Pinto D

更新日期：2015-06-01 00:00:00

abstract：:This study updates the geographic distributions of phlebotomine species in Central-West Brazil and analyses the climatic factors associated with their occurrence. The data were obtained from the entomology services of the state departments of health in Central-West Brazil, scientific collections and a literature revie...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Almeida PS,Andrade AJ,Sciamarelli A,Raizer J,Menegatti JA,Hermes SC,Carvalho Mdo S,Gurgel-Gonçalves R

更新日期：2015-06-01 00:00:00

abstract：:A pseudogene, designated as "ps(5.8S+ITS-2)", paralogous to the 5.8S gene and internal transcribed spacer (ITS)-2 of the nuclear ribosomal DNA (rDNA), has been recently found in many triatomine species distributed throughout North America, Central America and northern South America. Among characteristics used as crite...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Zuriaga MA,Mas-Coma S,Bargues MD

更新日期：2015-05-01 00:00:00

abstract：:The dissemination of plasmid-mediated antimicrobial resistance genes may pose a substantial public health risk. In the present work, the occurrences of blaCTX-M and plasmid-mediated ampC and qnr genes were investigated in Escherichia coli from 16 chicken carcasses produced by four commercial brands in Brazil. Of the b...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Botelho LA,Kraychete GB,Costa e Silva JL,Regis DV,Picão RC,Moreira BM,Bonelli RR

更新日期：2015-04-01 00:00:00

abstract：:Sandfly prevalence in the Kani tribe settlements of Western Ghats in India was investigated. A total of 1,279 sandflies comprising 17 species was obtained. Sandfly abundance showed a negative correlation (r = -0.97, p = 0.003) with increase in altitudinal ranges from 0-1,000 m. When sandfly samples were grouped accord...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ranganathan S,Swaminathan S

更新日期：2015-04-01 00:00:00

abstract：:This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydrodistilled. Using broth microdilution techniques, the obtained EOs were tested against th...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Houël E,Gonzalez G,Bessière JM,Odonne G,Eparvier V,Deharo E,Stien D

更新日期：2015-02-01 00:00:00

abstract：:Angiostrongylus cantonensis is the etiologic agent of eosinophilic meningoencephalitis in humans. Cases have been recorded in many parts of the world, including Brazil. The aim of this study was to compare the differences in the biology and morphology of two different Brazilian haplotypes of A. cantonensis: ac8 and ac...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Monte TC,Gentile R,Garcia J,Mota E,Santos JN,Maldonado Júnior A

更新日期：2014-12-01 00:00:00

abstract：:A longitudinal study was conducted in Manaus, Brazil, to monitor changes of adult Aedes aegypti (L.) abundance. The objectives were to compare mosquito collections of two trap types, to characterise temporal changes of the mosquito population, to investigate the influence of meteorological variables on mosquito collec...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Degener CM,Ázara TM,Roque RA,Codeço CT,Nobre AA,Ohly JJ,Geier M,Eiras ÁE

更新日期：2014-12-01 00:00:00